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Table 1 Characteristics of selected study articles

From: High burden of hypovitaminosis D among the children and adolescents in South Asia: a systematic review and meta-analysis

Authors

Year

Country

Study area (urban or rural)

Study design

Age

Gender

Socio economic status

Vitamin D estimation method

Sample size (N)

Average level of vitamin D (ng/mL)

Standard deviation (S.D.)

Marwaha et al. [26]

2005

India

Urban

Community—CS

10–18 y

Both

Both

RIA

5137

11.8

7.2

Sahu et al. [27]

2008

India

Rural

Community—CS

10–20 y

Both

Lower

RIA

155

20.16

9

Mandlik et al. [28]

2018

India

Rural

Community—CS

6–12 y

Both

NM

ELISA

359

23.4

4.12

Kapil et al. [29]

2017

India

NM

Community—CS

6–18 y

Both

Both

CLIA

626

11.8

5.475

Basu et al. [30] *

2014

India

Both

Hospital—CS

6–16 y

Both

NM

CLIA

154

13.5

12.22

Puri et al. [31]

2007

India

NM

Community—CS

6–18 y

Girls

Both

RIA

404

12.748

6.172

Kadam et al. [32]

2011

India

NM

Community—CS

8–12 y

Girls

Lower

RIA

214

24.74

10.48

Khadgawat et al. [33]

2013

India

NM

Community—RCT

10–14 y

Both

NM

CLIA

713

11.69

5.36

Chaudhuri et al. [34]

2016

India

NM

Hospital—CC

8–18 y

Both

NM

CMIA

50

22.5

NM

Sharawat et al. [35]

2019

India

Rural

Community—CS

5–10 y

Both

Lower

IRMA

100

17.652

9.912

Marwaha et al. [36]

2015

India

NM

Community—CS

10–15 y

Both

NM

CLIA

205

6.3

4.6

Sarma et al. [37]

2019

India

Both

Community—CS

8–14 y

Both

NM

RIA

500

37.7

0.93

Sanwalka et al. [38]

2012

India

NM

Community—CS

15–18 y

Girls

NM

RIA

120

8.88

4.384

Mandlik et al. [39]

2017

India

Rural

Community—RCT

6–12 y

Both

NM

ELISA

106

23.84

4.44

Borker et al. [40]

2009

India

NM

Hospital—CC

6–12 y

Both

NM

HPLC

50

26.16

12.28

Garg et al. [41]

2013

India

Urban

Community—CS

Mean age 14 y

Both

NM

RIA

1829

8.3

5.2

Khadilkar et al. [42]

2012

India

NM

Community—CS

8–12 y

Girls

Lower

RIA

214

24.73

10.65

Patel et al. [43]

2015

India

NM

Community—CS

10–14 y

Both

Both

CMIA

181

17.7

6.7

Marwaha et al. [44]

2017

India

NM

Community—CS

6–18 y

Girls

NM

CLIA

847

9.9

5.6

Prasad et al. [45]

2016

India

NM

Hospital—CC

< 3 y

Both

NM

ELISA

61

31

8.7

Agarwal et al. [46]

2012

India

NM

Hospital—CS

NM

Both

NM

RIA

336

6.15

NM

Basu et al. [30] *

2014

India

Both

Hospital—CS

1–5y

Both

Lower

CLIA

156

23

16.29

Wayse et al. [47]

2003

India

NM

Hospital—CC

2 m–5 y

Both

Middle

RIA

70

15.36

NM

Filteau et al. [48]

2015

India

NM

Community—CS

Mean age 5 y

Both

Lower

RIA

902

13.08

9.2

Taru et al. [49]

2015

India

NM

Hospital—CC

NM

Both

NM

NM

50

7.25

6.29

Sreedharan et al. [50]

2018

India

NM

Hospital—CC

2–13 y

Both

NM

ELISA

109

30.1

23.42

Agarwal et al. [51]

2010

India

Urban

Hospital—CS

10 weeks

Both

Lower

RIA

97

10.47

6.74

Mathur et al. [52]

2016

India

NM

Hospital—RCT

NM

Both

NM

ECLIA

50

12.65

10

Kumar et al. [53]

2011

India

NM

Hospital—RCT

6 months

Both

NM

RIA

237

14.4

10.2

Marwaha et al. [54]

2011

India

NM

Hospital—CS

6 weeks

Both

Lower

RIA

342

8.92

4.2

Agrawal et al. [55]

2019

India

Both

Hospital—CC

3 d–21 d

Both

NM

CLIA

50

14.88

7.2

Shukla et al. [56]

2016

India

NM

Hospital—CS

< 20 y

Both

NM

ECLIA

73

14.115

7.725

Schulze et al. [57]

2014

Nepal

Rural

Community—RCT

6–8 y

Both

NM

CIA

1000

26.52

7.4

Haugen et al. [58]

2016

Nepal

Urban

Community—CS

1–12 m

Both

NM

LCMS

466

32.8

8.56

Avagyan et al. [59]

2015

Nepal

Rural

Community—CS

1 y–5 y

Both

NM

LCMS

280

12.6

4.8

Marasinghe et al. [60]

2015

Sri Lanka

Urban

Community—CS

2–5 y

Both

NM

CLIA

340

23.5

8.97

Hettiarachchi et al. [61]

2010

Sri Lanka

NM

Hospital—CS

3–5 y

Both

NM

IRMA

248

33.71

14.1

Hettiarachchi et al. [62]

2011

Sri Lanka

NM

Hospital—CS

3–5 y

Both

NM

IRMA

105

24.78

0.66

Anwar et al. [63]

2015

Pakistan

Both

Community—CS

NM

Both

Lower

CLIA

227

9.884

7.334

Karim et al. [64]

2010

Pakistan

NM

Hospital—CS

NM

Both

Both

NM

50

20.4

10.99

Ahmed et al. [65]

2015

Bangladesh

Urban

Community—CS

0.5–2 y

Both

Both

EIA

913

21.86

16.67

Holland et al. [66]

2007

Afghanistan

NM

Community—CS

0.5–5 y

Both

NM

HPLC

107

5

NM

  1. RCT = Randomized control trial, CC = Case–control, CS = Cross-sectional, CIA = Commercial immunoassay, RIA = Radio immune assay, ELISA = Enzyme-linked immune sorbent assay, CLIA = Chemiluminescence immunoassay, CMIA = Chemiluminescent microparticle immune assay, IRMA = Immunoradiometric immunoassay, HPLC = High-performance liquid chromatography, LCMS = Liquid chromatography tandem mass spectroscopy, EIA = Enzyme Immunoassay, ECLIA = Electrochemiluminescence Immunoassay, NM = Not mention, y = Year m = Month, d = day
  2. *Belongs to a single study. This study was conducted on a population from two separate age groups (below-6 years and above-6 years) and therefore we segregated the sample size into two groups for our analysis