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Table 2 Study-specific case definition, methods of inflammatory diet assessment, and effect size model adjustments

From: Dietary inflammatory potential and the incidence of depression and anxiety: a meta-analysis

Study

Case definition

Criteria for case

Assessment of Inflammatory diet

Food parameters derived

Model adjustments

Lucas et al. [25]

Depression

Self-reported physician-diagnosed depression and regular antidepressant use (strict definition)

Measured CRP, IL-6, and TNF-a receptor 2

39

Age, BMI, total energy intake, smoking, physical activity, menopause status, HRT, marital status, retired, education, husband education, ethnicity, multivitamin use, reported diagnosis of cancer, high blood pressure, hypercholesterolemia, heart disease, diabetes, MHI-5 score at baseline, alcohol intake, caffeine intake

Sanchez-Villages et al. [29]

Depression

Use of antidepressants and/or physician diagnosis

DII

28

Age, BMI, smoking, physical activity during leisure time, use of vitamin supplements, total energy intake, presence of diseases at baseline (CVD, diabetes, hypertension, and dyslipidemia)

Akbaraly et al. [21]

Recurrent depressive symptoms

CES-D score ≥ 16 or treated by antidepressants

DII

27

Age, ethnicity, total energy intake, socioeconomic status, marital status, smoking habits, physical activity, alcohol intake, coronary heart diseases, type 2 diabetes, hypertension, HDL cholesterol, use of lipid-lowering drugs, central obesity, cognitive impairment

Shivappa et al. [31]

Depressive symptoms

CES-D-10 score ≥ 10

DII

26

Total energy intake, highest qualification completed, marital status, menopause status, night sweats, major personal illness or injury, smoking, physical activity, BMI, depression diagnosis or treatment

Wirth et al. [34]

Depressive symptoms

PHQ-9 score ≥ 10

DII

26

Race, education, marital status, perceived health, current infection status, family history of smoking, smoking status, past cancer diagnosis, arthritis, age, average nightly sleep duration

Bergmans et al. [22]

Depression

PHQ-9 score ≥ 10

DII

N/A?

Age, ethnicity, poverty income ratio category, employment status, health insurance status, educational status, marital status, BMI, smoking, physical activity, sedentary time, use of vitamin supplements, total energy intake, menopause (among women), any comorbidity (history of hypertension, dyslipidemia, diabetes, CVD, respiratory illness, or cancer)

Frequent anxiety

HRQOL: Frequent anxiety was defined as reporting feeling worried, tense, or anxious > 14 days out of the past 30

Adjibade et al. [35]

Depressive symptoms

CES-D (French) score ≥ 17 in men and ≥ 23 in women

DII

36

Age, intervention group during trial phase, education level, marital status, socio-professional status, energy intake without alcohol, number of 24-h dietary records, interval between the 2 CES-D measurements, smoking status, physical activity, BMI, cancer or cardiovascular events during follow-up

Phillips et al. [26]

Depressive symptoms

CES-D score ≥ 16

E-DII

26

Age, BMI, physical activity, smoking, alcohol consumption, antidepressant use, history of depression

Anxiety

HADS scores ≥ 13

Jorgensen et al. [24]

Depression

PHQ-9 score ≥ 10

DII

28

Race, education, annual household income, use of prescription cholesterol-lowering medication, lifetime history of cancer, BMI, physical activity, age, sex, current smoking status, taking dietary supplements in past 30 days, total energy intake

Salari-Moghaddam et al. [27]

Depression

HADS ≥ 8

DII

29

Age, sex, total energy intake, marital status education, family size, home ownership, antidepressant use, vitamin supplements use, smoking physical activity

Anxiety

HADS ≥ 8

Shivappa et al. [30]

Depressive symptoms

CES-D score ≥ 16

DII

24

Age, sex, race, BMI, education, smoking habits, yearly income, CES-D at baseline, statins use, NSAIDs or cortisone use

Shivappa et al. [32]

Depressive symptoms

DASS-21 (Persian) score > 9

DII

31

Age, energy, physical activity, BMI, smoking, presence of chronic disease, diet supplement use, salary, marital status

Vermeulen et al. [33]

Depression

CED-D score ≥ 20

Measured CRP, IL6 and TNF- a

10

Sex, age, marital status, education in years, depressive symptoms at baseline, smoking status, physical activity, antidepressant use, anti-inflammatory drugs, cardiovascular events, diabetes, waist circumference

Haghighatdoost et al. [23]

Depression

GHQ scores ≥ 12

DII

27

Age, marital status, education, BMI, smoking, physical activity, anti-psychotropic medicine use, suffering from gastrointestinal disorders

Adjibade et al. [20]

Depressive symptoms

CES-D ≥ 17 for men and ≥ 23 for women

ADII

34

Age, sex, marital status, educational, occupational categories, monthly household income, residential area, energy intake without alcohol, number of 24-h dietary records, alcohol intake, smoking status, physical activity, BMI, cancer, type 2 diabetes, and cardiovascular events

Açik et al. [19]

Depression

Zung Self-Rating Depression Scale ≥ 50

DII

29

Age, total energy intake, ethnicity, smoking, alcohol consumption, physical activity, minimally active, BMI and energy intake

Salari-Moghaddam et al. [28]

Depression

HADS ≥ 8

FDII

28

Age, sex, total energy intake, marital status education, family size, home ownership, antidepressant use, vitamin supplements use, smoking physical activity

Anxiety

HADS ≥ 8

  1. Key: TNF-a  tumor necrosis factor-alpha, CRP  C-reactive protein; IL-6  interleukin-6, BMI   body mass index, HRT   hormone replacement therapy, MHI-5   mental health inventory, DII   Dietary Inflammatory Index, CES-D   Center for Epidemiologic Studies Depression Scale, PHQ-9   Patient Health Questionnaire, HDL   high-density lipoproteins, PASE   Physical Activity Scale for the Elderly, DASS-21   Depression Anxiety and Stress Scale, NSAID   nonsteroidal anti-inflammatory drug, IADL   Lawton Instrumental Activities of Daily Living, HADS Hospital Anxiety and Depression Scale, GHQ-12   General Health Questionnaire, DII   Dietary Inflammation Index, E-DII   energy-adjusted DII, ADII  Alternate Dietary inflammatory Index, FDII   food-based dietary inflammatory index, HRQOL  Health-Related Quality of Life. Instrumental Activities of Daily Living, HADS  Hospital Anxiety and Depression Scale, GHQ-12   General Health Questionnaire, DII  Dietary Inflammation Index
  2. E-DII  energy-adjusted DII, ADII   Alternate Dietary inflammatory Index, FDII   food-based dietary inflammatory index, HRQOL   health-related quality of life