Skip to main content

Table 1 Summary of study characteristics

From: Maternal nutrition and its intergenerational links to non-communicable disease metabolic risk factors: a systematic review and narrative synthesis

 

Site

Study design

Number of participants

Age of adult offspring at follow-up

Exposure

Outcome

De Rooij et al. [14]

Netherlands

Cohort

672

58

Famine

Glucose metabolism (FPG, 120 minute glucose)

De Rooij et al. [15]

Netherlands

Cohort

783

58

Famine

Blood pressure (SBP, DBP)

Blood lipids

Glucose metabolism

Huang et al. [16]

China

Cohort

33247 (total N=35025)

32

Famine

Blood pressure (prevalence of hypertension)

Li et al. [17]

China

 

2959 (total N=7874)

43–45

Famine

Glucose metabolism: FPG, prevalence of hyperglycemia

Ravelli et al. [18]

Netherlands

Cohort

702

51–55

Famine

Glucose metabolism (FPG, 30 minute glucose, 120 minute glucose)

Blood lipids

Roseboom et al. [19]

Netherlands

Cohort

739

51–55

Famine

Blood pressure (SBP, DBP)

Roseboom et al. [20]

Netherlands

Cohort

704

50

Famine

Blood lipids (total cholesterol, LDL, HDL, LDL:HDL, Apo-A1, Apo-B)

Stanner et al. [21]

Russia

Cross-sectional

549

52–53

Famine

Blood pressure: SBP, DBP

Stein et al. [22]

Netherlands

Cohort

971

56–62

Famine

Blood pressure (SBP, DBP, prevalence of hypertension)

Wang et al. [23]

China

Cross-sectional

2420 (total N=6445)

52–53

Famine

Blood pressure: (SBP, DBP, prevalence of hypertension)

Blood lipids

Glucose metabolism

Zheng et al. [24]

China

Cross-sectional

3696 (total N=5040)

44–51

Famine

Blood pressure (SBP, DBP, prevalence of hypertension)

Blood lipids

Glucose metabolism

Loos et al. [25]

Belgium

Cross-sectional

800

18–34

GWG, ppBMI

Glucose metabolism (FPG, fasting plasma proinsulin, fasting plasma insulin, HOMA-IR, HOMA)

Mamun et al. [26]

Australia

Cohort

2271

21

GWG

Blood pressure (SBP, DBP)

Hochner et al. [27]

Israel

Cohort

1130

32

GWG, ppBMI

Blood pressure (SBP, DBP)

Blood lipids

Glucose metabolism

Hrolfsdottir et al. [28]

Denmark

Cohort

308

19–20

GWG

Blood pressure (SBP, DBP)

Blood lipids

Glucose metabolism

Mi et al. [29]

China

Cross-sectional

627

41–47

GWG

BMI

Blood pressure(SBP, DBP, prevalence of hypertension)

Blood lipids

Glucose metabolism

Scheers-Andersson et al. [30]

Sweden

Cohort

9816

18.3

GWG

Blood pressure (SBP, DBP, prevalence of hypertension)

Webb et al. [31]

Guatemala

Longitudinal

450

21–29

GWG, BMI, dietary intake (protein and micronutrient supplementation)

Blood pressure (SBP, DBP)

Hochner et al. [27]

Israel

Cohort

1130

32

GWG, ppBMI

Blood pressure (SBP, DBP)

Blood lipids

Glucose metabolism

Loos et al. [25]

Belgium

Cross-sectional

800

18–34

GWG, ppBMI

Glucose metabolism (FPG, fasting plasma proinsulin, fasting plasma insulin, HOMA-IR, HOMA)

Mi et al. [29]

China

Cross-sectional

627

41–47

GWG, BMI

Blood pressure (SBP, DBP)

Blood lipids

Glucose metabolism

Webb et al. [31]

Guatemala

Longitudinal

450

21–29

GWG, BMI, dietary intake (protein and micronutrient supplementation)

Blood pressure (SBP, DBP)

Campbell et al. [32]

UK

Cohort

253

40.6

Maternal dietary intake: protein, animal protein, fat, carbohydrate, calcium, vitamin A, thiamine, riboflavin, niacin, vitamin C

Blood pressure (SBP, DBP)

Conlisk et al. [33]

Guatemala

Longitudinal

429

24.4

Maternal dietary intake: protein and micronutrient supplementation

Glucose metabolism (FPG)

Danielsen et al. [34]

Denmark

Cohort

428

20

Maternal dietary intake: GI, GL

Blood pressure (SBP, DBP)

Blood lipids

Glucose metabolism

Macleod et al. [35]

UK

RCT

118

22–23

Maternal dietary intake: protein and carbohydrate supplementation

Blood pressure (SBP, DBP)

Blood lipids

Glucose metabolism

Roseboom et al. [36]

Netherlands

Cohort

739

50

Maternal dietary intake: protein/carbohydrate ratio

Blood pressure (SBP, DBP)

Rytter et al. [37]

Denmark

RCT

243

18–19

Maternal dietary intake: fish oil supplementation

Blood lipids (total cholesterol, LDL, HDL, TAG, Apo-A1, Apo-B)

Rytter et al. [38]

Denmark

RCT

180

19

Maternal dietary intake: fish oil supplementation

Blood pressure (SBP, DBP)

Rytter et al. [39]

Denmark

Cohort

443

19–20

Maternal dietary intake: fish oil supplementation

Blood pressure (SBP, DBP)

Shiell et al. [40]

UK

Cohort

626

27–30

Maternal dietary intake: meat and fish consumption plus low carbohydrate

Blood pressure (SBP, DBP)

Webb et al. [31]

Guatemala

Longitudinal

450

21–29

GWG, BMI, dietary intake (protein and micronutrient supplementation)

Blood pressure (SBP, DBP)

  1. GWG, gestational weight gain; BMI, body mass index; ppBMI, pre-pregnancy body mass index; GI, GlycFPG = Fasting Plasma Glucose; SBP, systolic blood pressure; DBP, diastolic blood pressure; HDL, high-density lipoprotein; LDL, low-density lipoprotein; TAG, triacylglycerides; HOMA-IR, homeostatic model assessment for insulin resistance