Association between ESR1 rs2234693 single nucleotide polymorphism and uterine fibroids in Taiwanese premenopausal and postmenopausal women

Table 2 Association between ESR1 rs2234693 and uterine fibroids

Variable	OR (95% CI)	p value
ESR1 rs2234693 (ref.: TT)
TC	0.87 (0.72–1.05)	0.147
CC	0.70 (0.52–0.93)	0.015*
p-trend	0.012*
Menopause (ref.: No)
Yes	0.69 (0.51–0.92)	0.012*
Alcohol consumption (ref.: No)
Yes	1.25 (0.71–2.21)	0.445
Age (ref.: 30–39 years)
40–49	2.96 (2.16–4.06)	< 0.001*
50–59	4.55 (3.09–6.69)	< 0.001*
60–69	2.59 (1.59–4.21)	< 0.001*
Level of education (ref.: Elementary school)
High school	1.05 (0.75–1.48)	0.780
University and above	1.00 (0.69–1.44)	0.982
Cigarette smoking (ref.: No)
Yes	1.01 (0.64–1.60)	0.9708
Exercise (ref.: No)
Yes	1.02 (0.84–1.23)	0.876
BMI	0.99 (0.97–1.02)	0.659
Second-hand smoke exposure (ref.: No)
Yes	1.25 (0.95–1.64)	0.117
Diabetes (ref.: No)
Yes	1.06 (0.80–1.40)	0.697
Hypertension (ref.: No)
Yes	1.32 (1.04–1.67)	0.021*
Tea consumption (ref.: No)
Yes	1.03 (0.85–1.26)	0.765
Coffee consumption (ref.: No)
Yes	1.05 (0.86–1.27)	0.631
Vegetarian diet (ref.: No)
Yes	0.84 (0.62–1.13)	0.254
Age at menarche (ref.: age at menarche ≤ 12)
12 < age at menarche ≤ 13	0.93 (0.72–1.21)	0.611
13 < age at menarche ≤ 14	0.87 (0.67–1.13)	0.302
Age at menarche > 14	0.88 (0.66–1.17)	0.372
Hormone use (ref.: No)
Yes	1.21 (0.94–1.55)	0.147
Herbal medicine use (ref.: No)
Yes	1.50 (1.14–1.97)	0.004*
Family history of uterine fibroids (ref.: No)
Yes	1.60 (1.28–2.00)	< 0.001*
Miscarriage/abortion (ref.: No)
Yes	1.24 (1.02–1.49)	0.030*
Parity	0.91 (0.82–1.01)	0.066

ESR1 Estrogen receptor 1, OR Odds ratio, CI Confidence interval, ref. reference
*Denotes statistical significance at p < 0.05

ISSN: 2072-1315