Table 3 Association between ESR1 rs2234693 and uterine fibroids stratified by menopausal status

ESR1 rs2234693 (ref.: TT)

TC

0.76 (0.59–0.98)

0.0371*

1.06 (0.79–1.40)

0.714

CC

0.64 (0.43–0.95)

0.0263*

0.78 (0.50–1.20)

0.255

P-trend

0.010*

0.431

Alcohol consumption (ref.: No)

Yes

1.29 (0.63–2.64)

0.482

1.21 (0.46–3.17)

0.698

Age

30–39

Ref

–

NA

NA

40–49

2.88 (2.08–3.99)

 < 0.001*

Ref

–

50–59

4.14 (2.71–6.31)

 < 0.001*

2.18 (0.97–4.94)

0.061

60–69

NA

NA

1.18 (0.51–2.74)

0.693

Level of education (ref.: Elementary school)

High school

0.93 (0.43–2.02)

0.858

1.07 (0.72–1.59)

0.728

University and above

0.82 (0.37–1.80)

0.616

1.20 (0.76–1.88)

0.437

Cigarette smoking (ref.: No)

Yes

0.96 (0.55–1.68)

0.896

1.07 (0.46–2.47)

0.880

Exercise (ref.: No)

Yes

1.07 (0.82–1.40)

0.616

0.93 (0.70–1.22)

0.585

BMI

1.00 (0.96–1.04)

0.994

0.98 (0.93–1.02)

0.313

Second-hand smoke exposure (ref.: No)

Yes

1.23 (0.87–1.74)

0.239

1.30 (0.82–2.06)

0.271

Diabetes (ref.: No)

Yes

1.22 (0.76–1.96)

0.417

0.96 (0.68–1.36)

0.825

Hypertension (ref.: No)

Yes

1.20 (0.80–1.78)

0.375

1.40 (1.04–1.88)

0.025*

Tea consumption (ref.: No)

Yes

0.96 (0.74–1.25)

0.763

1.15 (0.84–1.57)

0.375

Coffee consumption (ref.: No)

Yes

1.16 (0.90–1.50)

0.243

0.90 (0.66–1.22)

0.481

Vegetarian diet (ref.: No)

Yes

1.12 (0.78–1.62)

0.541

0.49 (0.29–0.85)

0.012*

Age at menarche (ref.: age at menarche ≤ 12)

12 < age at menarche ≤ 13

0.98 (0.71–1.37)

0.911

0.88 (0.57–1.37)

0.583

13 < age at menarche ≤ 14

0.82 (0.58–1.15)

0.239

0.92 (0.61–1.41)

0.712

Age at menarche > 14

0.67 (0.44–1.00)

0.051

1.10 (0.72–1.68)

0.656

P-trend

0.030*

NA

Hormone use (ref.: No)

Yes

1.19 (0.79–1.79)

0.408

1.23 (0.89–1.69)

0.217

Herbal medicine use (ref.: No)

Yes

1.68 (1.21–2.36)

0.002*

1.22 (0.73–2.03)

0.454

Family history of uterine fibroids (ref.: No)

Yes

1.88 (1.41–2.51)

 < 0.001*

1.24 (0.86–1.80)

0.258

Miscarriage/abortion (ref.: No)

Yes

1.40 (1.08–1.82)

0.012*

1.06 (0.80–1.40)

0.704

Parity

0.95 (0.82–1.10)

0.488

0.87 (0.75–1.02)

0.082