Association between ESR1 rs2234693 single nucleotide polymorphism and uterine fibroids in Taiwanese premenopausal and postmenopausal women

Table 4 Risk of uterine fibroids based on ESR1 rs2234693 genotypes and menopausal status

Variable	n	OR (95% CI)	p value
ESR1 rs2234693 genotypes and menopausal status (ref.: TT, no menopause)	775
TC, no menopause	927	0.75 (0.58–0.97)	0.030*
CC, no menopause	292	0.66 (0.45–0.97)	0.034*
TT, menopause	620	0.58 (0.41–0.84)	0.004*
TC, menopause	751	0.60 (0.42–0.85)	0.004*
CC, menopause	223	0.43 (0.27–0.70)	0.001*

Adjusted for age, level of education, cigarette smoking, exercise, BMI, second-hand smoke exposure, diabetes, hypertension, tea/coffee consumption, vegetarian diet, age at menarche, hormone/herbal medicine use, family history of uterine fibroids, miscarriage/abortion, and parity
ESR1 Estrogen receptor 1, OR Odds ratio, CI Confidence interval, ref. Reference
*Denotes statistical significance at p < 0.05

ISSN: 2072-1315