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Table 2 Mixed model analysis for longitudinal follow-up of liver function parameters

From: High-dose vitamin D supplementation is related to an improvement in serum alkaline phosphatase in COVID-19 patients; a randomized double-blinded clinical trial

Variable

Time effect

Group effect

Time* group effect

ALT

Beta

 − 1.25

10.97

 − 0.32

P-value

0.47

0.14

0.82

AST

Beta

 − 2.21

1.79

 − 0.22

P-value

0.006

0.76

0.84

ALP

Beta

3.4

34.92

 − 6.02

P-value

0.11

0.6

0.04

GGT

Beta

 − 1.19

 − 2.71

 − 0.11

P-value

0.004

0.73

0.73

LDH

Beta

 − 1.69

2.86

 − 3.46

P-value

0.003

0.51

0.67

  1. Bold values indicate statistically significant (P < 0.05)
  2. ALT: Alanine Aminotransferase, AST: Aspartate Aminotransferase, GGT: Gamma-Glutamyl Transpeptidase, ALP: Alkaline Phosphatase, LDH: Lactate dehydrogenase