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Table 1 Characteristics of patients classified by VZV reactivation

From: The effect of varicella-zoster virus reactivation on the long-term outcomes of patients undergoing allogeneic hematopoietic stem cell transplantation

 

All patients

Patients without VZV reactivation

Patients with VZ reactivation

P Value

No. of patients

219

169

50

 

Patient age (y)

   

0.188

 Median (range)

32 (14- 58)

31 (14- 58)

35.5 (16- 57)

 

Patient sex

   

0.554

 Female

82 (37.4%)

61 (36.1%)

21 (42.0%)

 

 Male

137 (62.6%)

108 (63.9%)

29 (58.0%)

 

Disease type

   

0.914

 AML

106 (48.4%)

82 (48.5%)

24 (48.0%)

 

 ALL

94 (42.9%)

73 (43.2%)

21 (42.0%)

 

 Others*

19 (8.68%)

14 (8.28%)

5 (10.0%)

 

Disease risk index

   

0.954

 Low

2 (0.91%)

2 (1.18%)

0 (0.00%)

 

 Intermediate

188 (85.8%)

142 (84.0%)

44 (88.0%)

 

 High

29 (13.2%)

23 (13.6%)

6 (12.0%)

 

Donor type

   

0.389

 Matched related

78 (35.6%)

61 (36.1%)

17 (34.0%)

 

 Mismatched related

124 (56.6%)

94 (55.6%)

30 (60.0%)

 

 Matched unrelated

9 (4.11%)

6 (3.55%)

3 (6.00%)

 

 Mismatched unrelated

8 (3.65%)

8 (4.73%)

0 (0.00%)

 

Sex matched

   

0.276

 Matched

109 (49.8%)

88 (52.1%)

21 (42.0%)

 

 Mismatched

110 (50.2%)

81 (47.9%)

29 (58.0%)

 

Donor sex

   

0.341

 Female

69 (31.5%)

50 (29.6%)

19 (38.0%)

 

 Male

150 (68.5%)

119 (70.4%)

31 (62.0%)

 

Donor age (y)

   

0.516

 Median (range)

31 (11- 62)

30 (11- 62)

33 (14- 60)

 

Conditioning regimen

   

1.000

 NMAC

1 (0.46%)

1 (0.59%)

0 (0.00%)

 

 MAC

214 (99.5%)

168 (99.4%)

50 (100%)

 

ATG

   

0.463

 No

50 (22.8%)

41 (24.3%)

9 (18.0%)

 

 Yes

169 (77.2%)

128 (75.7%)

41 (82.0%)

 

DLI

   

0.870

 No

189 (86.3%)

145 (85.8%)

44 (88.0%)

 

 Yes

30 (13.7%)

22 (14.2%)

6 (12.0%)

 

aGvHD

   

0.850

 Grade: 0–1

123 (56.2%)

96 (56.8%)

27 (54.0%)

 

 Grade: 2–4

96 (43.8%)

73 (43.2%)

23 (46.0%)

 

cGvHD

   

0.113

 No

120 (54.8%)

98 (58.0%)

22 (44.0%)

 

 Yes

99 (45.2%)

71 (42.0%)

28 (56.0%)

 

CMV reactivation

   

0.285

 No

91 (41.6%)

74 (43.8%)

17 (34.0%)

 

 Yes

128 (58.4%)

95 (56.2%)

33 (66.0%)

 
  1. MA myeloablative conditioning; NMAC, non-myeloablative conditioning; ATG, antithymocyte globulin; DLI, donor lymphocyte infusion; GvHD, graft versus host disease; CMV reactivation, cytomegalovirus reactivation
  2. *Others indicate 8 CML patients and 11 MDS patients