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Table 4 Subgroup analysis of the regulating effect of adherence to the MD on the association between osteopenia and the risk of all-cause mortality in general population

From: Adherence to the Mediterranean diet regulates the association between osteopenia and the risk of all-cause mortality in general population

Subgroup

Variables

Osteopenia = No

Osteopenia = Yes

Adherence to the MD

HR (95% CI)

P

HR (95% CI)

P

Age

 < 65 (n = 3123)

Low

0.91 (0.58–1.44)

0.690

1.49 (0.64–3.45)

0.350

High

1.00 (Ref)

 

1.21 (0.74–1.97)

0.451

 ≥ 65 (n = 2329)

Low

1.19 (0.92–1.55)

0.178

1.99 (1.36–2.91)

 < 0.001

High

1.00 (Ref)

 

1.64 (1.24–2.15)

 < 0.001

Gender

 Male (n = 2939)

Low

1.07 (0.83–1.38)

0.610

2.14 (1.31–3.50)

0.002

High

1.00 (Ref)

 

1.52 (1.07–2.17)

0.020

 Female ( n = 2513)

Low

1.14 (0.59–2.22)

0.690

1.61 (0.97–2.67)

0.066

High

1.00 (Ref)

 

1.41 (0.94–2.13)

0.100

BMI

 Underweight & Normal (n = 1417)

Low

1.55 (0.93–2.57)

0.092

1.96 (1.05–3.64)

0.034

High

1.00 (Ref)

 

1.65 (1.01–2.70)

0.045

 Overweight (n = 2098)

Low

0.98 (0.70–1.38)

0.922

1.73 (0.91–3.28)

0.095

High

1.00 (Ref)

 

1.36 (0.93–1.99)

0.115

 Obesity (n = 1937)

Low

0.93 (0.61–1.42)

0.743

1.60 (0.93–2.76)

0.091

High

1.00 (Ref)

 

1.51 (0.85–2.68)

0.163

CVDs

 No (n = 4427)

Low

0.91 (0.63–1.32)

0.618

1.80 (1.20–2.70)

0.005

High

1.00 (Ref)

 

1.46 (1.01–2.11)

0.042

 Yes (n = 1025)

Low

1.47 (1.09–1.98)

0.011

1.83 (1.08–3.10)

0.025

High

1.00 (Ref)

 

1.78 (1.19–2.66)

0.005

  1. Ref reference, HR hazard ratio, CI confidence Interval, MD Mediterranean diet, BMI body mass index, CVDs cardiovascular diseases
  2. Multivariable model, if not stratified, adjusted for age, race, education, marital status, PIR, smoking, hypertension, CVDs, previous fracture, glucocorticoid use, anti-osteoporosis therapy, total 25 Hydroxyvitamin D, energy, calcium, and BMI
  3. In female subgroup, menopausal and hormonetherapy were also adjusted