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Table 2 Association between Mn and NAFLD

From: Blood manganese and non-alcoholic fatty liver disease in a high manganese exposure area in China

 

Quartile 1

Quartile 2

Quartile 3

Quartile 4

P trend

All

     

Cut-off (μg/L)

 < 10.70

10.70–13.01

13.02–16.22

 > 16.22

 

Model 1

1

1.311 (1.051,1.633)

1.509 (1.211,1.88)

1.791 (1.435,2.236)

0.002

Model 2

1

1.354 (1.082,1.693)

1.552 (1.241,1.941)

1.962 (1.563,2.462)

 < 0.001

Model 3

1

1.279 (0.9553,1.717)

1.346 (1.004,1.806)

1.646 (1.222,2.217)

0.045

Females

     

Cut-off (μg/L)

 < 11.04

11.04–13.47

13.48–17.69

 > 17.69

 

Model 1

1

1.283 (0.696,2.367)

1.282 (0.692,2.374)

2.064 (1.168,3.648)

0.002

Model 2

1

1.279 (0.691,2.365)

1.279 (0.686,2.383)

2.056 (1.162,3.638)

0.002

Model 3

1

1.767 (0.680,4.592)

2.212 (0.852,5.743)

3.146 (1.285,7.701)

0.087

Males

     

Cut-off (μg/L)

 < 10.59

10.59–12.90

12.91–16.05

 > 16.05

 

Model 1

1

1.363 (1.072,1.733)

1.604 (1.262,2.039)

1.918 (1.497,2.457)

0.035

Model 2

1

1.364 (1.073,1.735)

1.605 (1.262,2.041)

1.922 (1.499,2.464)

0.039

Model 3

1

1.262 (0.922,1.727)

1.313 (0.960,1.795)

1.494 (1.082,2.061)

0.19

  1. The data are presented as odds ratio (95% confidence interval). The logistic regression models are constructed with data of the control group of those with blood Mn concentration in the lowest quartile
  2. Model 1: univariate model;
  3. Model 2: age-, sex-adjusted model for the total population and age-adjusted for the males and females;
  4. Model 3: Further adjusted for metabolic equivalents, alanine transaminase, total cholesterol, triglycerides, low-density lipoprotein, gamma-glutamyl transpeptidase, hypertension, diabetes, smoking, and drinking status