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Table 3 Association between Mn and NAFLD with different severity

From: Blood manganese and non-alcoholic fatty liver disease in a high manganese exposure area in China

  

Quartile 1

Quartile 2

Quartile 3

Quartile 4

All

Fibrosis-4

    
 

Score

    
 

 < 1.30 (n = 1004)

1

1.406 (1.038,1.906)

1.417 (1.047,1.919)

1.795 (1.323,2.435)

 

 ≥ 1.30 (n = 134)

1

0.818 (0.467,1.430)

1.069 (0.617,1.849)

1.032 (0.581,1.835)

 

ALT (U/L)

    
 

 < 40 (n = 677)

1

1.320 (0.969,1.798)

1.355 (0.995,1.844)

1.717 (1.259,2.343)

 

 ≥ 40 (n = 461)

1

1.090 (0.658,1.805)

1.211 (0.735,1.994)

1.488 (0.909,2.436)

Female

Fibrosis-4

    
 

Score

    
 

 < 1.30 (n = 113)

1

1.955 (0.783,4.880)

2.114 (0.842,5.303)

3.816 (1.567,9.294)

 

 ≥ 1.30 (n = 13)

1

1.739 (0.282,10.748)

3.884 (0.440,34.307)

5.807 (0.919,36.697)

 

ALT (U/L)

    
 

 < 40 (n = 99)

1

1.838 (0.757,4.463)

2.121 (0.869,5.173)

3.906 (1.635,9.333)

 

 ≥ 40 (n = 27)

–

–

–

–

Male

Fibrosis-4

    
 

Score

    
 

 < 1.30 (n = 891)

1

1.278 (0.922,1.772)

1.469 (1.059,2.037)

1.559 (1.126,2.160)

 

 ≥ 1.30 (n = 121)

1

0.773 (0.425,1.405)

1.246 (0.696,2.229)

0.818 (0.441,1.518)

 

ALT (U/L)

    
 

 < 40 (n = 578)

1

1.241 (0.888,1.734)

1.442 (1.031,2.019)

1.493 (1.067,2.088)

 

 ≥ 40 (n = 434)

1

1.022 (0.609,1.717)

1.270 (0.760,2.121)

1.286 (0.780,2.121)

  1. The data are presented as odds ratio (95% confidence interval). The multinomial logistic regression models are constructed with data of the control group of non-NAFLD subjects and unexposed group of those with blood Mn concentration in the lowest quartile
  2. The model was adjusted for age, sex (only for the total population), metabolic equivalents, alanine transaminase, total cholesterol, triglycerides, low-density lipoprotein, gamma-glutamyl- transpeptidase, hypertension, diabetes, smoking, and drinking status
  3. NAFLD, non-alcoholic fatty liver disease; Mn, manganese