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Table 2 Hazard ratios and 95% confidence intervals for all-cause and cardiovascular disease mortality according to serum 25(OH)D concentration in individuals with prehypertension

From: Association of serum 25-hydroxyvitamin D concentrations with all-cause and cardiovascular mortality among US adults with prehypertension: a prospective cohort study

 

No. of death (%)

Hazard ratios and 95% confidence intervals‡

Model 1

Model 2

Model 3

All-cause mortality

Categorical serum 25(OH)D concentration

    

 Severe deficiency

18 (9.0)

0.87 (0.41–1.88)

2.58 (1.31–5.05)

2.83 (1.46–5.52)

 Moderate deficiency

82 (6.6)

0.63 (0.38–1.04)

1.11 (0.68–1.82)

1.17 (0.74–1.86)

 Insufficient

122 (7.2)

0.80 (0.50–1.26)

1.30 (0.89–1.88)

1.36 (0.93–1.98)

 Sufficient

113 (9.4)

1 (Ref)

1 (Ref)

1 (Ref)

Continuous serum 25(OH)D concentration, per 10 nmol/L increase

 

1.04 (0.98–1.10)

0.92 (0.86–0.98)

0.91 (0.85–0.97)

CVD mortality

Categorical serum 25(OH)D

    

 Severe deficiency

6 (3.0)

0.49 (0.09–2.63)

3.10 (0.87–11.05)

4.14 (1.10–15.51)

 Moderate deficiency

18 (1.5)

0.49 (0.13–0.82)

1.22 (0.44–3.39)

1.23 (0.46–3.28)

 Insufficient

34 (2.0)

0.78 (0.25–2.49)

1.53 (0.83–2.80)

1.73 (0.96–3.14)

 Sufficient

30 (2.5)

1 (Ref)

1 (Ref)

1 (Ref)

Continuous serum 25(OH)D, per 10 nmol/L increase

 

1.07 (0.94–1.21)

0.87 (0.76–0.98)

0.86 (0.76–0.98)

  1. Hazard ratios and 95% confidence intervals were calculated by weighted Cox proportional hazards models. CVD, cardiovascular disease; 25(OH)D, 25-hydroxyvitamin D
  2. Model 1 was unadjusted. Model 2 adjusted for age, sex, ethnicity, education level, marital status, smoking status, drinking status, sedentary activity, total energy intake, sodium intake, potassium intake, overweight/obesity, and vitamin D supplement use. Model 3 adjusted for variables included in Model 2 plus comorbidities such as diabetes, hypercholesterolemia, heart failure, coronary heart disease, stroke, and cancer