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Polycystic ovarian disease and associated factors


The article by Ebrahimi-Mamaghani M et al. is quite informative and focuses on insulin resistance and lipid profile [1]. We work in a research organization which supports extramural and intramural research and would therefore like to know more on some aspects of this study as stated below.

  1. 1.

    The authors state that lipid abnormality may occur in polycystic ovary syndrome (PCOS) irrespective of insulin resistance (IR) in overweight and obese women. Indian literature showed that about one fourth of PCOS women have normal body mass index (BMI) [2]. PCOS women with normal BMI are very difficult to treat and monitor. Does the lipid abnormality exit in this category of women also, and will it help in monitoring of the PCOS women with normal BMI?

  2. 2.

    The main focus of this study is on overweight and obese PCOS women. This classification is dependent on BMI, but waist circumference has not been considered. However, many studies indicate that waist circumference is a more sensitive parameter to define obesity [3, 4]. We would like to know whether authors have found any relationship between waist circumference, hyperlipidemia, and IR. This information is important in monitoring response of the patients to treatment. Reduction in waist circumference is a non-invasive indicator of successful treatment and will be useful in low-resource settings also.

  3. 3.

    In the present study, prevalence of IR is 36.7 %, which is higher than that of previously reported studies [5]. Obesity is the underlying cause of the development of IR. Is this high prevalence reported largely because of the overweight and obese women? We would like to know whether the authors recommend IR documentation in all the PCOS women irrespective of BMI and whether IR investigation would be helpful in monitoring treatment in PCOS women irrespective of BMI.

  4. 4.

    Age has been reported as an important factor in the development of PCOS. IR and obesity also develop over a period of time and increase with age [6]. We would request the authors to discuss the relationship of IR in different age groups in a study population.

  5. 5.

    The authors have reported lower testosterone level among patients with IR. What would be the suggested underlying mechanism for this finding? Did they find any relationship with estrogen level? Free testosterone level has a positive correlation with HOMA-IR in postmenopausal women but not in premenopausal women [7]. Postmenopausal women are considered to have lower estrogenic levels than premenopausal women. In this respect, knowing estrogen level in PCOS women is important.


  1. Ebrahimi-Mamaghani M, Saghafi-Asl M, Pirouzpanah S, Aliasgharzadeh A, Aliashrafi S, Rezayi N, Mehrzad-Sadaghiani M. Association of insulin resistance with lipid profile, metabolic syndrome, and hormonal aberrations in overweight or obese women with polycystic ovary syndrome. J Health Popul Nutr. 2015;33(1):157–67.

    PubMed  PubMed Central  Google Scholar 

  2. Ramanand SJ, Ghongane BB, Ramanand JB, Patwardhan MH, Ghanghas RR, Jain SS. Clinical characteristics of polycystic ovary syndrome in Indian women. Indian J Endocrinol Metab. 2013;17(1):138–45.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Elbassuoni E. Better association of waist circumference with insulin resistance and some cardiovascular risk factors than body mass index. Endocr Regul. 2013;47(1):3–14.

    Article  CAS  PubMed  Google Scholar 

  4. Takahara M, Kaneto H, Shimomura I. Insulin resistance can be easily estimated by body mass index and waist circumference in a general Japanese population. J AtherosclerThromb. 2013;20(4):401–3.

    Google Scholar 

  5. Mehrabian F, Khani B, Kelishadi R, Kermani N. The prevalence of metabolic syndrome and insulin resistance according to the phenotypic subgroups of polycystic ovary syndrome in a representative sample of Iranian females. J ResMed Sci. 2011;16(6):763–9.

    CAS  Google Scholar 

  6. Oya J, Nakagami T, Yamamoto Y, Fukushima S, Takeda M, Endo Y, et al. Effects of age on insulin resistance and secretion in subjects without diabetes. Intern Med. 2014;53(9):941–7.

    Article  PubMed  Google Scholar 

  7. Matsui S, Yasui T, Tani A, Kunimi K, Uemura H, Yamamoto S, et al. Associations of estrogen and testosterone with insulin resistance in pre- and postmenopausal women with and without hormone therapy. Int J Endocrinol Metab. 2013;11(2):65–70.

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Jyoti Thulkar.

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JT conceived the idea of writing the letter, and after the discussion with SS, final drafting was done. Both JT and SS agreed to the content in the final Letter to Editor.

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Thulkar, J., Singh, S. Polycystic ovarian disease and associated factors. J Health Popul Nutr 35, 10 (2016).

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