Skip to main content

Advertisement

You are viewing the new article page. Let us know what you think. Return to old version

Letter to the Editor | Open | Published:

Polycystic ovarian disease and associated factors

Sir,

The article by Ebrahimi-Mamaghani M et al. is quite informative and focuses on insulin resistance and lipid profile [1]. We work in a research organization which supports extramural and intramural research and would therefore like to know more on some aspects of this study as stated below.

  1. 1.

    The authors state that lipid abnormality may occur in polycystic ovary syndrome (PCOS) irrespective of insulin resistance (IR) in overweight and obese women. Indian literature showed that about one fourth of PCOS women have normal body mass index (BMI) [2]. PCOS women with normal BMI are very difficult to treat and monitor. Does the lipid abnormality exit in this category of women also, and will it help in monitoring of the PCOS women with normal BMI?

  2. 2.

    The main focus of this study is on overweight and obese PCOS women. This classification is dependent on BMI, but waist circumference has not been considered. However, many studies indicate that waist circumference is a more sensitive parameter to define obesity [3, 4]. We would like to know whether authors have found any relationship between waist circumference, hyperlipidemia, and IR. This information is important in monitoring response of the patients to treatment. Reduction in waist circumference is a non-invasive indicator of successful treatment and will be useful in low-resource settings also.

  3. 3.

    In the present study, prevalence of IR is 36.7 %, which is higher than that of previously reported studies [5]. Obesity is the underlying cause of the development of IR. Is this high prevalence reported largely because of the overweight and obese women? We would like to know whether the authors recommend IR documentation in all the PCOS women irrespective of BMI and whether IR investigation would be helpful in monitoring treatment in PCOS women irrespective of BMI.

  4. 4.

    Age has been reported as an important factor in the development of PCOS. IR and obesity also develop over a period of time and increase with age [6]. We would request the authors to discuss the relationship of IR in different age groups in a study population.

  5. 5.

    The authors have reported lower testosterone level among patients with IR. What would be the suggested underlying mechanism for this finding? Did they find any relationship with estrogen level? Free testosterone level has a positive correlation with HOMA-IR in postmenopausal women but not in premenopausal women [7]. Postmenopausal women are considered to have lower estrogenic levels than premenopausal women. In this respect, knowing estrogen level in PCOS women is important.

References

  1. 1.

    Ebrahimi-Mamaghani M, Saghafi-Asl M, Pirouzpanah S, Aliasgharzadeh A, Aliashrafi S, Rezayi N, Mehrzad-Sadaghiani M. Association of insulin resistance with lipid profile, metabolic syndrome, and hormonal aberrations in overweight or obese women with polycystic ovary syndrome. J Health Popul Nutr. 2015;33(1):157–67.

  2. 2.

    Ramanand SJ, Ghongane BB, Ramanand JB, Patwardhan MH, Ghanghas RR, Jain SS. Clinical characteristics of polycystic ovary syndrome in Indian women. Indian J Endocrinol Metab. 2013;17(1):138–45.

  3. 3.

    Elbassuoni E. Better association of waist circumference with insulin resistance and some cardiovascular risk factors than body mass index. Endocr Regul. 2013;47(1):3–14.

  4. 4.

    Takahara M, Kaneto H, Shimomura I. Insulin resistance can be easily estimated by body mass index and waist circumference in a general Japanese population. J AtherosclerThromb. 2013;20(4):401–3.

  5. 5.

    Mehrabian F, Khani B, Kelishadi R, Kermani N. The prevalence of metabolic syndrome and insulin resistance according to the phenotypic subgroups of polycystic ovary syndrome in a representative sample of Iranian females. J ResMed Sci. 2011;16(6):763–9.

  6. 6.

    Oya J, Nakagami T, Yamamoto Y, Fukushima S, Takeda M, Endo Y, et al. Effects of age on insulin resistance and secretion in subjects without diabetes. Intern Med. 2014;53(9):941–7.

  7. 7.

    Matsui S, Yasui T, Tani A, Kunimi K, Uemura H, Yamamoto S, et al. Associations of estrogen and testosterone with insulin resistance in pre- and postmenopausal women with and without hormone therapy. Int J Endocrinol Metab. 2013;11(2):65–70.

Download references

Acknowledgements

None to declare.

Author information

Correspondence to Jyoti Thulkar.

Additional information

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

JT conceived the idea of writing the letter, and after the discussion with SS, final drafting was done. Both JT and SS agreed to the content in the final Letter to Editor.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Keywords

  • Insulin Resistance
  • Waist Circumference
  • Testosterone Level
  • Premenopausal Woman
  • Obese Woman